What is Leukodystrophy?


Leukodystrophies are a group of rare, genetic disorders affecting the white matter in the brain. Leuko means “white” and dystrophy means “abnormal growth.” Leukodystrophy damages the myelin sheath in the brain which leads to improper communication between the brain and other parts of the body. Most leukodystrophies are neurodegenerative and progressive thereby worsening the condition with time. Very few leukodystrophies have a treatment or cure.

Types


At present, there are nearly 50 identified leukodystrophies although many are still unclassified. The most common types are:

  • Aicardi-Goutieres syndrome
  • Alexander disease
  • CADASIL
  • Canavan disease
  • CARASIL
  • Fabry disease
  • GM1 gangliosidosis
  • Krabbe disease
  • Sjogren-Larsson syndrome

Each type of leukodystrophy affects a different part of the myelin sheath leading to different neurological problems in each type.

Signs and Symptoms


Signs and symptoms can begin immediately after birth or even appear in childhood or adulthood depending on the type and severity. Symptoms also depend on the area of the brain affected. Some common symptoms are:

  • Problems with motor skills like standing and walking
  • Seizures
  • Cognitive loss
  • Regression of developmental milestones like loss of speech

Since leukodystrophy is a neurodegenerative, progressive condition symptoms become more severe with age:

  • Trouble walking or standing
  • Trouble with speech
  • Decline of vision and hearing
  • Regressive mental development
  • Trouble with eating and swallowing

Since most leukodystrophies do not have a treatment, it is important to work with a multidisciplinary group of specialists to prevent physical and mental loss of abilities.

Diagnosis


If the pediatrician/physician/neurologists suspects one of the leukodystrophy types, he/she will usually take a family history and history of the child’s/adult’s symptoms along with a detailed clinical examination. Some of the tests that are used to diagnose leukodystrophies include:

  • physical examination to check for muscle wasting and weakness
  • MRI for detailed imaging of the brain
  • nerve conduction tests
  • genetic testing - to check for various genotypes

Currently, newborn screening can pick up two types of leukodystrophies, Krabbe disease and adrenoleukodystrophy. However, these panels are rarely done in India.

Please see list of specialized genetic testing centres

 leukodystrophies
Genetic testing is available for some types of leukodystrophies
Image Source : Pixabay

Treatment


Currently, no specific treatment or cure is available for the leukodystrophies except for Fabry disease and ALD. Fabry disease is currently treatable with enzyme replacement therapy (ERT) with enzyme agalsidase beta. This is given through intravenous infusion every 15 days to prevent further physical and cognitive decline. ALD if diagnosed early can be halted with bone marrow transplant (BMT) which can prevent further neurological decline.

For the rest of the leukodystrophies, treatment is aimed at preventing complications and enabling independent living. An interdisciplinary team of doctors including pediatricians, neurologists, orthopedicians, pulmonologists and physiotherapists will be required to take care of the clinical needs of the child/adult. In the early stages when just diagnosed, it is important to immediately start physiotherapy and rehab to prevent further deterioration and maintain a certain level of mobility.

Physiotherapy is highly recommended to preserve muscle strength. Wheelchairs may be required in some cases. Adaptive devices are also useful to perform daily tasks.

Living with Leukodystrophy


Children and adults with leukodystrophy must be encouraged to participate in all life activities and must be encouraged to go to regular schools, colleges and participate in social activities to the extent possible. Genetic counselling and psychosocial counselling must be made available whenever required with other supportive measures.

Look up our list of patient organizations in India for help and support

 leukodystrophies
Children must be encouraged to engage in physical activities
Image Source : Pixabay

Prenatal Testing and Leukodystrophy


If there is a known case of leukodystrophy in the family, it is absolutely essential for closest female relatives like siblings, uncles, aunts and cousins to test for carrier status.

If a woman with a carrier status is pregnant, prenatal test is essential to determine if the fetus has the disease mutation.

Look up our list of clinical geneticists and testing centres in India for help and support

Mail us on namitha@strandlf.org if you require any further information or want to contribute a resource for this page

Article and Journal Links:


Videos:


Leukodystrophies - Causes, Symptoms, Treatments & More…
https://youtu.be/IgJS6hMn9V0

Fabry's Disease: What You Should Know | Anjay Rastogi, MD, PhD
https://youtu.be/yZwxAODrq-g